what inside the covid virus?

Introduction

Today the whole world is suffering from the pandemic. Thousands of people are dying every day from this virus. I think this is the most dangerous situation ever made from the 19th century till now. 
But if we see back to our past we have come across many types of despises more daily than the present coved 19. For example the 'small pox' in 19th century UK mate with this despises and lost more the 3lakh people but they have also recovered from that situation.
If we see our track records we will see India has faced many desires more dangerous than coved 19 and have recovered from it.
Then what is special in the despises
which we call 'COVID-19'? let's find out...

 

The emergence of SARS-CoV and SARS-CoV-2

In November 2002, SARS began spreading from the Guangdong province of Southern China, but its reservoir was unknown. In the past, Nipah and Hendra, both zoonotic viruses, originated from bats, and this motivated researchers to find whether bats are the natural reservoirs of SARS-CoV. In 2005, 2 research groups independently reported that bats (horseshoe bats in particular) are the natural host of genetically diverse coronaviruses and closely related to those responsible for the SARS outbreak. These viruses were termed SARS-like coronaviruses, and they displayed considerable genetic similarities to SARS-CoV isolated from humans or civets. This suggested that the virus responsible for the SARS outbreak was a member of the SARS-like coronaviruses group. In Saudi Arabia, MERS-CoV emerged in 2012, when humans were infected through direct or indirect contacts with infected dromedary camels. However, genome analysis suggested that MERS-CoV might have also originated in bats and was transmitted to camels in the distant past 

 Structure of the SARS-CoV-2 RNA-dependent RNA polymerase complex

Coronaviruses use an RNA-dependent RNA polymerase (RdRp) complex for replication of their genome and transcription of their genes . The SARS-CoV-2 RdRp complex is composed of a catalytic subunit nsp12 and two accessory subunits nsp7 and nsp8, which increase RdRp template binding and processivity. The mechanism of replication and inhibition of SARS-CoV-2 RdRp has been elucidated by several groups using cryo-EM structures of the RdRp–nps7–nsp8 complex , its complex with RNA , and Remdesivir . The overall structure of the SARS-CoV-2 nsp12–nsp7–nsp8 complex highly resembles that of SARS-CoV, with a global root-mean-square deviation (RMSD) of approximately 1 Å for the α-carbon atoms. The SARS-CoV-2 RdRp complex structure reveals that the nsp12 core catalytic subunit is bound to a heterodimer of nsp7–nsp8 and an additional nsp8 subunit at a different binding site. The N-terminus of nsp12 contains iridovirus RdRp-associated nucleotidyltransferase (NiRAN) domain followed by an interface domain and a C-terminal RdRp domain. The RdRp domain includes 7 conserved motifs (A–G) distributed in the finger, palm, and thumb subdomains. The palm subdomain is formed by 5 conserved motifs A–E; motif C contains a critical SDD sequence (“Ser-Asp-Asp” residues 759–761), which forms the catalytic active center. Both D760 and D761 coordinate with 2 magnesium ions at the catalytic center. The F and G motifs are located within the finger subdomain and direct the template strand RNA into the active site, and the thumb subdomain intersects the extensions from the finger subdomain to hold the first turn of RNA. The residues involved in RNA binding as well as forming the catalytic active site are highly conserved among different RNA viruses, which highlights the conserved mechanism of genome replication used by RdRp. 

for more information about the structure click here

conclusion

At present things we can do is to wash our hands regularly. And to ware mask all times. Avoid going out of the house and take care of our selves and also others.